3-(2-氯苯基)-1H-吡咯合成路线 （共 6 条）
反应条件
ethanolamine
T=170°C; 1 h;
参考文献
Sakai; Suzuki; Nunami; Yoneda; Onoda; Iwasawa
Chemical and pharmaceutical bulletin, 1980 , vol. 28, # 8 p. 2384 - 2393
反应条件
1: 80 percent / 1.) n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -70 - 20 °C
2: DIBAL / toluene / -70 °C
3: 2N HCl / Ambient temperature
4: methanolic ammonium acetate
View Scheme
参考文献
Mendez, Jose Manuel; Flores, Blas; Leon, Fernando; Martinez, Maria Eugenia; Vazquez, Alfredo; Garcia, Gustavo Alberto; Salmon, Manuel
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4099 - 4102
反应条件
1: DIBAL / toluene / -70 °C
2: 2N HCl / Ambient temperature
3: methanolic ammonium acetate
View Scheme
参考文献
Mendez, Jose Manuel; Flores, Blas; Leon, Fernando; Martinez, Maria Eugenia; Vazquez, Alfredo; Garcia, Gustavo Alberto; Salmon, Manuel
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4099 - 4102
反应条件
1: 83 percent / NaOH / methanol; H2O / 18 h / 50 °C
2: 64 percent / etanolamine / 1 h / 170 °C
View Scheme
参考文献
Sakai; Suzuki; Nunami; Yoneda; Onoda; Iwasawa
Chemical and pharmaceutical bulletin, 1980 , vol. 28, # 8 p. 2384 - 2393
反应条件
1: 56 percent / NaH (65percent in oil) / tetrahydrofuran / 3 h / 40 - 50 °C
2: 83 percent / NaOH / methanol; H2O / 18 h / 50 °C
3: 64 percent / etanolamine / 1 h / 170 °C
View Scheme
参考文献
Sakai; Suzuki; Nunami; Yoneda; Onoda; Iwasawa
Chemical and pharmaceutical bulletin, 1980 , vol. 28, # 8 p. 2384 - 2393
反应条件
1.) anhydrous benzene, diisobutylaluminium hydride(in toluene), 20 deg C, 3h 2.) 1.5 M aqueous sodium dihydrogen phosphate, reflux, 30 min; Yield given. Multistep reaction;
参考文献
Babler, James H.; Spina, Kenneth P.
Tetrahedron Letters, 1984 , vol. 25, # 16 p. 1659 - 1660
