(S)-N-叔丁氧羰基-3-氨基-3-苯基丙-1-醇合成路线 （共 18 条）
反应条件
1.1: 80 percent / sodium azide / dimethylformamide / 48 h / 80 °C 2.1: 88 percent / Et3N; hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr 3.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C 3.2: 82 percent / tetrahydrofuran; various solvent(s) / 2 h / 0 °C 4.1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating 5.1: 81 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
1: 4-DMAP / CH2Cl2 2: 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine 3: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1589 - 1592
反应条件
1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating 2: 81 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
1.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C 1.2: 82 percent / tetrahydrofuran; various solvent(s) / 2 h / 0 °C 2.1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating 3.1: 81 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
in dichloromethane T=20°C; 8 h;
参考文献
US2013/345126 A1, ;
Paragraph 0292 ;
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile
参考文献
Tetrahedron Letters, , vol. 48, # 40 p. 7094 - 7098
反应条件
DMP in dichloromethane 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/9959 A1, 2005 ;
Location in patent: Page/Page column 51-52 ;
WO 2005/009959 A1
反应条件
1: PDC / dimethylformamide 2: diethyl ether View Scheme
参考文献
Alcon, Montserrat; Canas, Marc; Poch, Marta; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1994 , vol. 35, # 10 p. 1589 - 1592
