反式-4-(马来酰亚胺甲基)环己烷羧酸-NHS合成路线 （共 6 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 4 h;
参考文献
Kimura, Sadaaki; Masunaga, Shin-Ichiro; Harada, Tomohiro; Kawamura, Yasuo; Ueda, Satoshi; Okuda, Kensuke; Nagasawa, Hideko
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1721 - 1728
反应条件
2,4,6-trimethyl-pyridine in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Paterson, Michael J.; Eggleston, Ian M.
Synthetic Communications, 2008 , vol. 38, # 2 p. 303 - 308
反应条件
1: 1-hydroxy-pyrrolidine-2,5-dione With trifluoroacetic anhydride in N,N-dimethyl-formamide
T=0°C; 0.166667 h; Inert atmosphere;
2: With 2,4,6-trimethyl-pyridine in N,N-dimethyl-formamide
T=0°C; 0.166667 h; Inert atmosphere;
3: N-(carboxyacryloyl)-4-(aminomethyl)-cyclohexane-1-carboxylic acid in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Leonard, Nicholas M.; Brunckova, Jarmila
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9169 - 9174
反应条件
1: 1-hydroxy-pyrrolidine-2,5-dione With trifluoroacetic anhydride in N,N-dimethyl-formamide
T=0°C; 0.166667 h; Inert atmosphere;
2: With 2,4,6-trimethyl-pyridine in N,N-dimethyl-formamide
T=0°C; 0.166667 h; Inert atmosphere;
3: N-(carboxyacryloyl)-4-(aminomethyl)-cyclohexane-1-carboxylic acid in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Leonard, Nicholas M.; Brunckova, Jarmila
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9169 - 9174
反应条件
1.1: acetonitrile / 6 h / 20 °C / Inert atmosphere
2.1: trifluoroacetic anhydride / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
2.2: 0.17 h / 0 °C / Inert atmosphere
2.3: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Leonard, Nicholas M.; Brunckova, Jarmila
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9169 - 9174
反应条件
dicyclohexyl-carbodiimide
1) THF, 1.5h, 2a) 0 deg C, 5 min, 2b) RT, 24h; Yield given. Multistep reaction;
参考文献
Nielsen; Buchardt
Synthesis, 1991 , # 10 p. 819 - 821
