1-二苯甲基-1H-咪唑合成路线 （共 11 条）
反应条件
Na2K-SG(I) in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Nandi, Partha; Dye, James L.; Jackson, James E.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3864 - 3866
反应条件
1: 89 percent / acetonitrile / 49 h / 105 °C 2: amberlist A-26, bromide form / ethanol / 0.75 h / 20 °C 3: 35 percent / 1 h / 200 °C / 1 Torr View Scheme
参考文献
Alcalde, Ermitas; Mesquida, Neus; Alemany, Montserrat; Alvarez-Rua, Carmen; Garcia-Granda, Santiago; Pacheco, Pedro; Perez-Garcia, Lluisa
European Journal of Organic Chemistry, 2002 , # 7 p. 1221 - 1231
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=-5 - 20°C; 2.5 h; Inert atmosphere;
参考文献
Doiron, Jeremie; Soultan, Al Haliffa; Richard, Ryan; Toure, Mamadou Mansour; Picot, Nadia; Richard, Remi; Cuperlovic-Culf, Miroslava; Robichaud, Gilles A.; Touaibia, Mohamed
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4010 - 4024
反应条件
potassium hydroxide; potassium carbonate; tetrabutylammomium bromide in xylene
Heating;
参考文献
Claramunt, Rosa M.; Elguero, Jose; Garceran, Rafael
Heterocycles, 1985 , vol. 23, # 11 p. 2895 - 2906
反应条件
1: With phosphoric acid in 1,4-dioxane; water
T=80°C; pH=2; 0.5 h;
2: With ammonium chloride in 1,4-dioxane; water
T=100°C; 3 h; Further stages.;
参考文献
Perry, Marc C.; Cui, Xiuhua; Powell, Mark T.; Hou, Duen-Ren; Reibenspies, Joseph H.; Burgess, Kevin
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 113 - 123
反应条件
in acetonitrile
T=20°C; Substitution; 2 h;
参考文献
Njar
Synthesis, 2000 , # 14 p. 2019 - 2028
反应条件
in diphenylether
0.5 h; Heating;
参考文献
Corelli; Summa; Brogi; Monteagudo; Botta
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2008 - 2015
反应条件
1: 94 percent / DEAD, Ph3P / tetrahydrofuran / 24 h / Ambient temperature
2: 97 percent / NaOH / ethanol / 24 h / Heating
3: 90 percent / diphenyl ether / 0.5 h / Heating
View Scheme
参考文献
Corelli; Summa; Brogi; Monteagudo; Botta
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2008 - 2015
反应条件
1: 97 percent / NaOH / ethanol / 24 h / Heating
2: 90 percent / diphenyl ether / 0.5 h / Heating
View Scheme
参考文献
Corelli; Summa; Brogi; Monteagudo; Botta
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2008 - 2015
反应条件
1: acetonitrile / 85.5 h / Heating
2: 20 percent / 0.5 h / 70 °C / 1 Torr
View Scheme
参考文献
Alcalde, Ermitas; Mesquida, Neus; Alemany, Montserrat; Alvarez-Rua, Carmen; Garcia-Granda, Santiago; Pacheco, Pedro; Perez-Garcia, Lluisa
European Journal of Organic Chemistry, 2002 , # 7 p. 1221 - 1231
