1,2,4-噻唑[4,3-b]吡嗪e, 6-氯-3-苯基-合成路线 （共 12 条）
反应条件
1: With triethyl amine hydrochloride in para-xylene
24 h; Heating / reflux;
2: With potassium carbonate in water
参考文献
AMOREPACIFIC CORPORATION; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY; CRYSTALGENOMICS, INC.
Patent: WO2008/69500 A1, 2008 ;
Location in patent: Page/Page column 12-13 ;
反应条件
chloramine-T in 2-methyl tetrahydrofuran
T=60°C; 1.5 h; Inert atmosphere;
参考文献
Thiel, Oliver R.; Achmatowicz, Michal M.
Organic Syntheses, 2013 , vol. 90, p. 287 - 300
反应条件
[Ph3SnF2][NBu4] in tetrahydrofuran
T=20°C; Substitution;
参考文献
Collins, Ian; Castro, Jose L.; Street, Leslie J.
Tetrahedron Letters, 2000 , vol. 41, # 5 p. 781 - 784
反应条件
tris(dimethylamino)-sulphonium difluorotrimethylsilicate in tetrahydrofuran
T=20°C; Substitution;
参考文献
Collins, Ian; Castro, Jose L.; Street, Leslie J.
Tetrahedron Letters, 2000 , vol. 41, # 5 p. 781 - 784
反应条件
zirconium tetrachloride in 1,4-dioxane
23 h; Heating;
参考文献
Pozgan, Franc; Polanc, Slovenko; Kocevar, Marijan
Heterocycles, 2001 , vol. 54, # 2 p. 1011 - 1019
反应条件
zirconium tetrachloride in 1,4-dioxane
0.25 h; Heating;
参考文献
Pozgan, Franc; Polanc, Slovenko; Kocevar, Marijan
Heterocycles, 2001 , vol. 54, # 2 p. 1011 - 1019
反应条件
trichlorophosphate in acetonitrile
T=80°C; 16 h;
参考文献
Grey, Ron; Pierce, Albert C.; Bemis, Guy W.; Jacobs, Marc D.; Moody, Cameron Stuver; Jajoo, Rahul; Mohal, Narinder; Green, Jeremy
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3019 - 3022
反应条件
1: 97 percent / (BrCl2C)2; PPh3 / acetonitrile / 0 °C
2: 25 percent / [(Me2N)3S][Me3SiF2] / tetrahydrofuran / 20 °C
View Scheme
参考文献
Collins, Ian; Castro, Jose L.; Street, Leslie J.
Tetrahedron Letters, 2000 , vol. 41, # 5 p. 781 - 784
反应条件
1: 89 percent / methanol / 1 h / 20 °C
2: 26 percent / ZrCl4 / dioxane / 0.25 h / Heating
View Scheme
参考文献
Pozgan, Franc; Polanc, Slovenko; Kocevar, Marijan
Heterocycles, 2001 , vol. 54, # 2 p. 1011 - 1019
反应条件
acetic acid
T=200°C; 0.166667 h; Microwave irradiation;
参考文献
Aldrich, Leslie N.; Lebois, Evan P.; Michelle Lewis; Nalywajko, Natalia T.; Niswender, Colleen M.; David Weaver; Jeffrey Conn; Lindsley, Craig W.
Tetrahedron Letters, 2009 , vol. 50, # 2 p. 212 - 215
