3H-螺[1-苯并呋喃-2,4-哌啶]合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in isopropyl alcohol
T=70°C; P=3040.2 Torr; 8 h;
参考文献
SEPRACOR INC.; CHYTIL, Milan; ENGEL, Sharon, R.; FANG, Qun, Kevin
Patent: WO2010/144571 A1, 2010 ;
Location in patent: Page/Page column 128 ;
WO 2010/144571 A1
反应条件
1: 1.) Mg / 1.) iodine / 1.) ether, reflux, 20 h; 2.) ether, r.t., 2 h
2: 40 percent / 98percent sodium hydride / benzene; dimethylformamide / 5 h / 110 - 120 °C
3: 58 percent / H2 / 10percent palladium on charcoal / propan-2-ol / 65 - 70 °C / 2585.7 Torr
View Scheme
参考文献
Effland, Richard C.; Gardner, Beth Ann; Strupczewski, Joseph
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 811 - 814
反应条件
1: 40 percent / 98percent sodium hydride / benzene; dimethylformamide / 5 h / 110 - 120 °C
2: 58 percent / H2 / 10percent palladium on charcoal / propan-2-ol / 65 - 70 °C / 2585.7 Torr
View Scheme
参考文献
Effland, Richard C.; Gardner, Beth Ann; Strupczewski, Joseph
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 811 - 814
反应条件
1: 1.) Mg / 1.) iodine / 1.) ether, reflux, 20 h; 2.) ether, r.t., 2 h
2: 40 percent / 98percent sodium hydride / benzene; dimethylformamide / 5 h / 110 - 120 °C
3: 58 percent / H2 / 10percent palladium on charcoal / propan-2-ol / 65 - 70 °C / 2585.7 Torr
View Scheme
参考文献
Effland, Richard C.; Gardner, Beth Ann; Strupczewski, Joseph
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 811 - 814
反应条件
N-bromosuccinmide in methanol
T=0°C; 6 h;
参考文献
SEPRACOR INC.; CHYTIL, Milan; ENGEL, Sharon, R.; FANG, Qun, Kevin
Patent: WO2010/144571 A1, 2010 ;
Location in patent: Page/Page column 128-129 ;
WO 2010/144571 A1
