hydrogenchloride in tetrahydrofuran T=20 - 50°C; 22 h;

1: 1.) Mg / 1.) iodine / 1.) ether, reflux, 20 h; 2.) ether, r.t., 2 h 2: 81 percent / 50percent sodium hydride (oil dispersion) / benzene; dimethylformamide / 4 h / Heating 3: 1.) ethyl chloroformate; 2.) 50percent KOH / 1.) benzene, reflux, 24 h; 2.) ethanol, reflux, 18 h View Scheme

1: 1.) Mg / 1.) iodine / 1.) ether, reflux, 20 h; 2.) ether, r.t., 2 h 2: 81 percent / 50percent sodium hydride (oil dispersion) / benzene; dimethylformamide / 4 h / Heating 3: 1.) ethyl chloroformate; 2.) 50percent KOH / 1.) benzene, reflux, 24 h; 2.) ethanol, reflux, 18 h View Scheme

1: 81 percent / 50percent sodium hydride (oil dispersion) / benzene; dimethylformamide / 4 h / Heating 2: 1.) ethyl chloroformate; 2.) 50percent KOH / 1.) benzene, reflux, 24 h; 2.) ethanol, reflux, 18 h View Scheme

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C 1.2: 18 h / 40 °C 2.1: potassium tert-butylate / 40 h / 40 - 50 °C 3.1: hydrogenchloride / tetrahydrofuran View Scheme

1: potassium tert-butylate / 40 h / 40 - 50 °C 2: hydrogenchloride / tetrahydrofuran View Scheme

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C 1.2: 18 h / 40 °C 2.1: potassium tert-butylate / 40 h / 40 - 50 °C 3.1: hydrogenchloride / tetrahydrofuran View Scheme

potassium hydroxide; chloroformic acid ethyl ester 1.) benzene, reflux, 24 h; 2.) ethanol, reflux, 18 h; Yield given. Multistep reaction;