4-(3-(4-氟苯基)-1,2,4-噁二唑-5-基)双环[2.2.2]辛烷-1-羧酸甲酯合成路线 （共 2 条）
反应条件
1: bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 1 h;
2: 4-fluoro-N'-hydroxybenzimidamide in dichloromethane
T=20°C; 8 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/93516 A1, 2009 ;
Location in patent: Page/Page column 34 ;
US 20090093516 A1
反应条件
1: bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 1 h;
2: (Z)-4-fluoro-N'-hydroxybenzimidamide in dichloromethane
3: in toluene
16 h; Heating / reflux;
参考文献
Waddell, Sherman T.; Santorelli, Gina M.; Maletic, Milana M.; Leeman, Aaron H.; Gu, Xin; Graham, Donald W.; Balkovec, James M.; Aster, Susan D.
Patent: US2004/133011 A1, 2004 ;
Location in patent: Page 26-27 ;
