4-(4-甲基-5-(2-(三氟甲基)苯基)-4H-1,2,4-噻唑-3-基)双环[2.2.2]辛烷-1-羧酰胺合成路线 (共 3 条)
反应条件
1: With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 2 h;
2: With ammonia in dichloromethane; water
18 h;
参考文献
Waddell, Sherman T.; Santorelli, Gina M.; Maletic, Milana M.; Leeman, Aaron H.; Gu, Xin; Graham, Donald W.; Balkovec, James M.; Aster, Susan D.
Patent: US2004/133011 A1, 2004 ;
Location in patent: Page 35-36 ;
反应条件
1: With triethylamine; trifluoroacetic anhydride in dichloromethane
T=0°C; 0.583333 h;
2: With sodium hydrogencarbonate in dichloromethane
参考文献
GLAXOSMITHKLINE LLC; MARINO, Joseph, Paul; BROOKS, Carl, A.; EIDAM, Patrick; MCATEE, John, Jeffrey
Patent: WO2010/11917 A1, 2010 ;
Location in patent: Page/Page column 22 ;
WO 2010/011917 A1
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/87150 A2, 2007 ;
Location in patent: Page/Page column 28 ;