2,4-二乙氧基-5-甲基嘧啶合成路线 （共 12 条）
反应条件
anschliessende Hydrolyse mit methanol.HCl;
参考文献
Visser et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1926
参考文献
Schmidt-Nickels; Johnson
Journal of the American Chemical Society, 1930 , vol. 52, p. 4511,4514
参考文献
Sprague; Johnson
Journal of the American Chemical Society, 1935 , vol. 57, p. 2252,2253,2254
反应条件
1: ethanol
2: H2O / Einleiten von Chlor unter Kuehlung
3: ethanolic NaOH
View Scheme
参考文献
Sprague; Johnson
Journal of the American Chemical Society, 1935 , vol. 57, p. 2252,2253,2254
反应条件
1: POCl3
2: ethanol
3: H2O / Einleiten von Chlor unter Kuehlung
4: ethanolic NaOH
View Scheme
参考文献
Sprague; Johnson
Journal of the American Chemical Society, 1935 , vol. 57, p. 2252,2253,2254
反应条件
1: H2O / Einleiten von Chlor unter Kuehlung
2: ethanolic NaOH
View Scheme
参考文献
Sprague; Johnson
Journal of the American Chemical Society, 1935 , vol. 57, p. 2252,2253,2254
参考文献
Sprague; Johnson
Journal of the American Chemical Society, 1936 , vol. 58, p. 423,425
参考文献
Sprague; Johnson
Journal of the American Chemical Society, 1936 , vol. 58, p. 423,425
反应条件
1: 5-methyl-2,4(1H,3H)-pyrimidinedione With potassium hydride in N,N-dimethyl-formamide
T=60°C; 0.5 h;
2: diethyl sulphate in N,N-dimethyl-formamide
T=60°C; 48 h; Further byproducts given;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
反应条件
1: POCl3, N,N-diethylaniline / 10 h / 110 °C
2: ethanol / 0.25 h / 60 °C
View Scheme
参考文献
Pluskota; Jankowski; Koroniak
Synthetic Communications, 1992 , vol. 22, # 20 p. 2927 - 2934
