3-哌啶甲酸乙酯（盐酸盐）合成路线 （共 72 条）
反应条件
1: 65 percent / K2CO3, KI / acetone / 18 h / Ambient temperature 2: 38 percent / p-toluenesulfonic acid monohydrate / dimethylformamide; toluene / 1.25 h / Heating 3: 12 M aq. NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 12 p. 1716 - 1725
反应条件
1: NaCNBH3; CF3CH2OH; 3A sieves 2: H2 / Pd/C / methanol View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
参考文献
Xu, Ruo; Czarniecki, Michael; Man, Jos De; Pan, Jianping; Qiang, Li; Root, Yuriko; Ying, Shihong; Su, Jing; Sun, Xijun; Zhang, Yuping; Yu, Tao; Zhang, Yang; Hu, Tao; Chen, Shu-Hui
Tetrahedron Letters, 2011 , vol. 52, # 26 p. 3266 - 3270
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Reduction; 20 h;
参考文献
Sorensen, Mads D.; Khalifa, Nagy M.; Pedersen, Erik B.
Synthesis, 1999 , # 11 p. 1937 - 1943
反应条件
1: With L-(+)-tartaric acid 2: With potassium carbonate
参考文献
Yamanaka, Toshio; Ohkubo, Mitsuru; Takahashi, Fumie; Kato, Masayuki
Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2843 - 2845
反应条件
(2S,3S)-2,3-dihydroxybutanedioic acid
参考文献
PFIZER INC.
Patent: WO2004/74283 A1, 2004 ;
Location in patent: Page 111 ;
WO 2004/074283 A1
反应条件
1: sodium hydrogencarbonate / water / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 °C View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
反应条件
Ki in ethyl acetate; acetone
参考文献
Warner-Lambert Company
Patent: US4910312 A1, 1990 ;
反应条件
Ki; potassium carbonate in N,N-dimethylformamide (DMF); chloroform
参考文献
WARNER-LAMBERT COMPANY
Patent: EP221572 B1, 1991 ;
反应条件
1: 95 percent / Na2CO3 / CH2Cl2; H2O / 3 h / Heating 2: NH3; NaCN / 48 h / 55 °C View Scheme
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
