3-哌啶甲酸乙酯（盐酸盐）合成路线 （共 72 条）
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
Yao, Wenqing; Xu, Meizhong; Zhang, Colin; Li, Yanlong; Zhuo, Jincong; Metcalf, Brian W.
Patent: US2006/4049 A1, 2006 ;
Location in patent: Page/Page column 41 ;
US 20060004049 A1
反应条件
triethylamine in dichloromethane T=0°C; 4 h;
参考文献
Chang, Meng-Yang; Lin, Chung-Han; Lee, Tein-Wei
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 627 - 631
反应条件
2,2,2-trifluoroethanol; 3 A molecular sieve; sodium cyanoborohydride
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
hydrogenchloride 72 h; Heating;
参考文献
Wahlgren, Curtis G.; Addison, Anthony W.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 541 - 543
反应条件
1: 100 percent / Na2CO3 / acetonitrile / 15 h / Heating 2: aq. HCl / 4 h / Heating View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
1: piperidine-3-carboxylic acid ethyl ester With sodium hexamethyldisilazane in toluene T=-35 - -20°C; 0.5 h; 2: methyl iodide in toluene T=-25 - 20°C;
参考文献
MERCK FROSST CANADA and CO.
Patent: EP1015431 B1, 2005 ;
Location in patent: Page/Page column 28 ;
EP 1015431 B1
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 90 percent / tetrahydrofuran 2.1: 85 percent / TFA View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; EWING, William R.; ZHU, Yeheng; SUN, Chongqing; HUANG, Yanting; KARATHOLUVHU, Maheswaran Sivasamban
Patent: WO2013/12829 A1, 2013 ;
WO 2013/012829 A1
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1213281 A1, 2002 ;
反应条件
1: Lg-tartaric acid 2: H2O View Scheme
参考文献
Akkerman et al.
Recueil des Travaux Chimiques des Pays-Bas, 1951 , vol. 70, p. 899,913
反应条件
1: With L-(+)-tartaric acid 2: With potassium carbonate
参考文献
Yamanaka, Toshio; Ohkubo, Mitsuru; Takahashi, Fumie; Kato, Masayuki
Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2843 - 2845
