3-哌啶甲酸乙酯（盐酸盐）合成路线 （共 72 条）
反应条件
T=165°C; P=110326 Torr; Hydrogenation;
参考文献
Adkins et al.
Journal of the American Chemical Society, 1934 , vol. 56, p. 2425,2427
参考文献
Cohen et al.
British Journal of Pharmacology and Chemotherapy, 1957 , vol. 12, p. 194,206
反应条件
1: 93 percent / Huenig base / CH2Cl2 / 0 deg C to RT
2: 100 percent / 4 N NaOH / tetrahydrofuran / 48 h / Ambient temperature
View Scheme
参考文献
Villalgordo, Jose M.; Heimgartner, Heinz
Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222
反应条件
1: sodium hydrogencarbonate / water / 16 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 °C
3: sodium hydrogencarbonate; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane; water / 18 h / 20 °C
4: potassium carbonate; toluene-4-sulfonic acid; toluene-4-sulfonamide / toluene; ethylene glycol dimethyl ether; methanol / 20 h / 80 °C
5: hydrogenchloride / 1,4-dioxane; water / 16 h / 80 °C
View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
反应条件
1: 72 percent / 1.5 h / 180 °C
2: 74 percent / NaOH / H2O / 0.5 h / Heating
View Scheme
参考文献
Delaney, Edward J.; Wood, Leigh E.; Klotz, Irving M.
Journal of the American Chemical Society, 1982 , vol. 104, # 3 p. 799 - 807
反应条件
1: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C
2: sodium methylate / tetrahydrofuran / 1.75 h / Reflux
3: hydrogenchloride / dichloromethane; ethanol / 3 h / 40 °C
View Scheme
参考文献
MITHRIDION, INC.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; TWOSE, Trevor, M.; VERDONE, Melinda, L.
Patent: WO2012/33956 A1, 2012 ;
WO 2012/033956 A1
反应条件
1: triethylaamine / CH2Cl2 / 4 h / 0 °C
2: lithium aluminum hydride / tetrahydrofuran / 5 h / 0 °C
3: pyridinium chlorochromate; Celite / CH2Cl2 / 5 h / 20 °C
4: tetrahydrofuran / 5 h / -78 °C
5: pyridinium chlorochromate; Celite / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
反应条件
1: triethylaamine / CH2Cl2 / 4 h / 0 °C
2: lithium aluminum hydride / tetrahydrofuran / 5 h / 0 °C
3: pyridinium chlorochromate; Celite / CH2Cl2 / 5 h / 20 °C
4: tetrahydrofuran / 5 h / -78 °C
5: pyridinium chlorochromate; Celite / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
反应条件
1: triethylaamine / CH2Cl2 / 4 h / 0 °C
2: lithium aluminum hydride / tetrahydrofuran / 5 h / 0 °C
3: pyridinium chlorochromate; Celite / CH2Cl2 / 5 h / 20 °C
4: tetrahydrofuran / 5 h / -78 °C
5: pyridinium chlorochromate; Celite / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
反应条件
1: 90 percent / 12 h / 80 °C
2: 33 percent / t-BuOK / toluene / 3 h / Heating
View Scheme
参考文献
ABBOTT LABORATORIES
Patent: US2011/152248 A1, 2011 ;
