1: in methanol T=20°C; 0.25 h; 2: With acetyl chloride in methanol T=10 - 15°C; 3: With sodium hydrogencarbonate in methanol; water T=0 - 5°C; 2 h; Product distribution / selectivity;
参考文献
CALYX CHEMICALS AND PHARMACEUTICALS LTD.
Patent: WO2009/109989 A1, 2009 ;
Location in patent: Page/Page column 9-10 ;
1: in methanol T=20°C; 0.25 h; 2: With methanesulfonyl chloride in methanol T=10 - 20°C; 3: With sodium hydrogencarbonate in methanol T=20°C; 2 h; Product distribution / selectivity;
1: in methanol T=20°C; 0.25 h; 2: With chloro-trimethyl-silane in methanol T=10 - 20°C; 3: With sodium hydrogencarbonate in methanol T=20°C; 2 h; Product distribution / selectivity;
1: With sulfuric acid in methanol 2: With sulfuric acid in methanol 3: With sodium hydrogencarbonate in methanol; water Product distribution / selectivity;
1: β-dihydroartemisinin With 12-phosphotungstic acid*nH2O in dichloromethane T=20°C; 0.0833333 h; 2: methanol in dichloromethane T=20°C; 3 h; optical yield given as percent de;
