1: 98 percent / PPTs / methanol / 14 h / 22 °C 2: MnO2 / tetrahydrofuran / 5 h 3: NaCN / acetic acid / 16 h View Scheme

1: 75 percent / CBr4, BaCO3, Ph3P / CH2Cl2 / 0.75 h 2: 82 percent / n-Bu3SnH, AIBN / toluene / 1 h / 65 °C 3: 98 percent / PPTs / methanol / 14 h / 22 °C 4: MnO2 / tetrahydrofuran / 5 h 5: NaCN / acetic acid / 16 h View Scheme

1: 82 percent / n-Bu3SnH, AIBN / toluene / 1 h / 65 °C 2: 98 percent / PPTs / methanol / 14 h / 22 °C 3: MnO2 / tetrahydrofuran / 5 h 4: NaCN / acetic acid / 16 h View Scheme

1: 97 percent / pyridine / Ambient temperature 2: 90 percent / NaI / butan-2-one / 1.5 h / Heating 3: 81 percent / hexamethylphosphoric acid triamide / 0.5 h / Ambient temperature 5: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 6: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 7: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 8: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 9: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 10: 80 percent / 80percent aq CH3COOH / Ambient temperature 11: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme

1: 77 percent / diisobutylaluminium hydride / CH2Cl2; hexane / 0.5 h / -20 °C 2: 60 percent / triphenylphosphine, imidazole, diisopropylamine, iodine / diethyl ether; acetonitrile / 3 h / Ambient temperature 3: 70 percent / azoisobutyronitrile, tributyltin hydride / aq. ethanol / 12 h / Ambient temperature 4: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 5: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 6: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 7: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 8: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 9: 80 percent / 80percent aq CH3COOH / Ambient temperature 10: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme

2: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 3: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 4: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 5: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 6: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 7: 80 percent / 80percent aq CH3COOH / Ambient temperature 8: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme

1: 81 percent / hexamethylphosphoric acid triamide / 0.5 h / Ambient temperature 3: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 4: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 5: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 6: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 7: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 8: 80 percent / 80percent aq CH3COOH / Ambient temperature 9: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme

1: 90 percent / NaI / butan-2-one / 1.5 h / Heating 2: 81 percent / hexamethylphosphoric acid triamide / 0.5 h / Ambient temperature 4: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 5: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 6: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 7: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 8: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 9: 80 percent / 80percent aq CH3COOH / Ambient temperature 10: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme

1: 60 percent / triphenylphosphine, imidazole, diisopropylamine, iodine / diethyl ether; acetonitrile / 3 h / Ambient temperature 2: 70 percent / azoisobutyronitrile, tributyltin hydride / aq. ethanol / 12 h / Ambient temperature 3: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 4: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 5: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 6: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 7: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 8: 80 percent / 80percent aq CH3COOH / Ambient temperature 9: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme

1: 70 percent / azoisobutyronitrile, tributyltin hydride / aq. ethanol / 12 h / Ambient temperature 2: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 3: 97 percent / pyridinium chlorochromate, sodium acetate, Celite / CH2Cl2 / 1.5 h / Ambient temperature 4: 71 percent / tetrahydrofuran; diethyl ether / 1.8 h / -78 - 0 °C 5: 95 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature 6: 1.) sodium hydride / 1.) THF, RT, 1 h 2.) RT, overnight 7: 80 percent / 80percent aq CH3COOH / Ambient temperature 8: 77 percent / 1N aq NaHCO3, 1N aq KOH / ethanol; tetrahydrofuran / 4.5 h / 0 °C View Scheme