N-芴甲氧羰基-N'-叔丁氧羰基-L-赖氨酸合成路线 （共 31 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 2 h;
参考文献
Journal of Organic Chemistry, , vol. 77, # 23 p. 10575 - 10582
反应条件
1.1: 2M aq. NaHCO3; CuSO4*5H2O 1.2: NaHCO3 / H2O; acetone / 24 h 1.3: 8-quinolinol / H2O / 5 h 2.1: Na2CO3 / H2O; acetone / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
反应条件
1.1: 2M aq. NaHCO3; CuSO4*5H2O 1.2: NaHCO3 / H2O; acetone / 24 h 1.3: 8-quinolinol / H2O / 5 h 2.1: Na2CO3 / H2O; acetone / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
反应条件
sodium carbonate in water; acetone Acylation; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
参考文献
Karidi, Konstantina; Garoufis, Achilleas; Hadjiliadis, Nick; Reedijk, Jan
Dalton Transactions, 2005 , # 4 p. 728 - 734
反应条件
1: NH2-SAL resin; Fmoc-L-phenylalanine With benzotriazol-1-ol; diisopropyl-carbodiimide in N,N-dimethyl-formamide Rink amide resin; 2: With piperidine in N,N-dimethyl-formamide Rink amide resin; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-Fmoc-L-leucine; Fmoc-L-phenylalanine; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) Further stages;
参考文献
Wu, Haifan; Li, Yaqiong; Bai, Ge; Niu, Youhong; Qiao, Qiao; Tipton, Jeremiah D.; Cao, Chuanhai; Cai, Jianfeng
Chemical Communications, 2014 , vol. 50, # 40 p. 5206 - 5208
反应条件
1: With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate in tetrahydrofuran T=-15°C; Inert atmosphere; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=-15°C; Inert atmosphere;
参考文献
Bandyopadhyay, Anupam; Agrawal, Neha; Mali, Sachitanand M.; Jadhav, Sandip V.; Gopi, Hosahudya N.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 21 p. 4855 - 4860
反应条件
dicyclohexyl-carbodiimide in ethyl acetate 0 deg C, 1 h; r.t., 1 h;
参考文献
Kisfaludy, Lajos; Schoen, Istvan
Synthesis, 1983 , # 4 p. 325 - 327
反应条件
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Esterification;
参考文献
Pudhom, Khanitha; Vilaivan, Tirayut
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5939 - 5942
反应条件
pyridine in N,N-dimethyl-formamide 0.75 h; Ambient temperature;
参考文献
Green, Michael; Berman, Judd
Tetrahedron Letters, 1990 , vol. 31, # 41 p. 5851 - 5852
