N-芴甲氧羰基-N'-叔丁氧羰基-L-赖氨酸合成路线 （共 31 条）
反应条件
dimethyl sulfoxide T=120°C; 0.25 h; Microwave irradiation;
参考文献
Hoeck, Stefan; Marti, Roger; Riedl, Rainer; Simeunovic, Marina
Chimia, 2010 , vol. 64, # 3 p. 200 - 202
反应条件
piperidine in N,N-dimethyl-formamide 0.5 h;
参考文献
Cen, Yana; Falco, Jessica N.; Xu, Ping; Youn, Dou Yeon; Sauve, Anthony A.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 4 p. 987 - 993
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 0.25 h; 2: in N,N-dimethyl-formamide 3: Fmoc-Arg (Boc)2-OH; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) Further stages;
参考文献
Chemical Communications, , vol. 46, # 16 p. 2808 - 2810
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 1 h; solid phase reaction; 2: With piperidine in N,N-dimethyl-formamide 0.5 h; solid phase reaction; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-α-Fmoc-N-ω,N-ω'-bis-tert-butoxycarbonyl-L-arginine Further stages;
参考文献
Organic Process Research and Development, , vol. 14, # 6 p. 1313 - 1325
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 1 h; 2: With piperidine in N,N-dimethyl-formamide 0.5 h; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-α-Fmoc-N-ω,N-ω'-bis-tert-butoxycarbonyl-L-arginine Further stages;
参考文献
Organic Process Research and Development, , vol. 14, # 6 p. 1313 - 1325
反应条件
1.1: pyridine / tetrahydrofuran / 0.5 h / 0 °C 1.2: 2.67 h / 0 - 20 °C 2.1: piperidine / dichloromethane; acetonitrile / 24 h / 0 - 20 °C 3.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 0.17 h / Inert atmosphere 3.2: 1.17 h / 20 °C 4.1: dichloromethane / 0.5 h / 20 °C 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 20 h / 0 °C / Inert atmosphere View Scheme
参考文献
Madsen, Andreas S.; Olsen, Christian A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590
反应条件
1: N-Fmoc-L-leucine With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine Automated synthesizersolid phase reaction; 2: Automated synthesizersolid phase reaction; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc-L-phenylalanine; fmoc-L-Ile-OH; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH Further stages;
参考文献
Fernandez-Reyes, Maria; Diaz, Dolores; De La Torre, Beatriz G.; Cabrales-Rico, Ania; Valles-Miret, Mariona; Jimenez-Barbero, Jesus; Andreu, David; Rivas, Luis
Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5587 - 5596
反应条件
tin(IV) chloride in ethyl acetate 0.416667 h; Ambient temperature;
参考文献
Chemical Communications, , # 22 p. 2509 - 2510
反应条件
dicyclohexyl-carbodiimide in dichloromethane 12 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 4 p. 987 - 993
反应条件
1: TFA / CH2Cl2 / 1 h / 20 °C 2: 41.5 g / aq. NaOH / dioxane / 20 °C View Scheme
参考文献
Wang, Jun; Uttamchandani, Mahesh; Li, Ping Sun; Yao, Shao Q.
Chemical Communications, 2006 , # 7 p. 717 - 719
