1: 71 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt; DIPEA / CH2Cl2 / 0 - 20 °C 2: 92 percent / piperidine 3: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C 4: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0 View Scheme

1: 86 percent / aq. Cs2CO3 / ethanol; dimethylformamide / 20 °C 2: morpholine / CH2Cl2 / 20 °C View Scheme

1: C29H30NO7Pol With piperidine in N,N-dimethyl-formamide 0.333333 h; solid phase reaction; 2: N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in dichloromethane; N,N-dimethyl-formamide 2 h; solid phase reaction; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; fmoc-L-Ile-OH; fmoc-O-tert-butyl-L-tyrosine; fmoc-L-Arg(Pbf)-OH Further stages;

dimethyl sulfoxide T=120°C; 0.333333 h;

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane 2: piperidine / N,N-dimethyl-formamide View Scheme

1: N-Fmoc-D-Tyr(t-Bu)-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine TentaGel RRAM solid phase resin; 2: With piperidine in N,N-dimethyl-formamide T=50°C; 1 h; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; Fmoc-O-trityl-l-threonine; fmoc-Asn(trt)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine; Fmoc-Asp(OMpe)-OH; N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH; fmoc-L-Arg(Pbf)-OH Further stages;