Fmoc-O-叔丁基-L-酪氨酸合成路线 （共 31 条）
反应条件
sodium azide in N,N-dimethyl-formamide T=50°C; 5 h;
参考文献
Chen, Chun-Chi; Rajagopal, Basker; Liu, Xuan Yu; Chen, Kuan Lin; Tyan, Yu-Chang; Lin, Fui; Lin, Po-Chiao
Amino Acids, 2014 , vol. 46, # 2 p. 367 - 374
反应条件
1: 1.) i-BuOCOCl, N-methylmorpholine / 1.) THF, -20 deg C, 20 min; 2.) THF, Et2O, -5 deg C to RT, 4 h 2: 74 percent / H2O, CF3COOAg, N-methylmorpholine / tetrahydrofuran / 4 h / 0 deg C to RT View Scheme
参考文献
Abele, Stefan; Guichard, Gilles; Seebach, Dieter
Helvetica Chimica Acta, 1998 , vol. 81, # 12 p. 2141 - 2156
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 0.25 h; 2: in N,N-dimethyl-formamide 3: Fmoc-Arg (Boc)2-OH; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) Further stages;
参考文献
Chemical Communications, , vol. 46, # 16 p. 2808 - 2810
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 1 h; solid phase reaction; 2: With piperidine in N,N-dimethyl-formamide 0.5 h; solid phase reaction; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-α-Fmoc-N-ω,N-ω'-bis-tert-butoxycarbonyl-L-arginine Further stages;
参考文献
Organic Process Research and Development, , vol. 14, # 6 p. 1313 - 1325
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 1 h; 2: With piperidine in N,N-dimethyl-formamide 0.5 h; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-α-Fmoc-N-ω,N-ω'-bis-tert-butoxycarbonyl-L-arginine Further stages;
参考文献
Organic Process Research and Development, , vol. 14, # 6 p. 1313 - 1325
参考文献
Polish Journal of Chemistry, , vol. 66, # 8 p. 1269 - 1276
反应条件
1: N-(9-fluorenylmethoxycarbonyl)glycine With ethyl (hydroxylimino)cyanoacetate; diisopropyl-carbodiimide in N,N-dimethyl-formamide T=20°C; 1 h; 2: With piperidine in N,N-dimethyl-formamide 3: N-Fmoc-L-leucine; C27H27NO7S2; Fmoc–Pro–OH; fmoc-L-Ile-OH; fmoc-O-tert-butyl-L-tyrosine; fmoc-Asn(trt)-OH; fmoc-Gln(Trt)-OH Further stages;
参考文献
Postma, Tobias M.; Albericio, Fernando
Organic Letters, 2013 , vol. 15, # 3 p. 616 - 619
反应条件
diisopropyl-carbodiimide in tetrahydrofuran 2 h;
参考文献
Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Taylor, John E.; Moyer, Brian R.; Dean, Richard T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1361 - 1371
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
Roviello, Giovanni N.; Musumeci, Domenica; Bucci, Enrico M.; Pedone, Carlo
International Journal of Pharmaceutics, 2011 , vol. 415, # 1-2 p. 206 - 210
反应条件
1: C29H30NO7Pol With piperidine in N,N-dimethyl-formamide
0.333333 h; solid phase reaction;
2: N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in dichloromethane; N,N-dimethyl-formamide
2 h; solid phase reaction;
3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; fmoc-L-Ile-OH; fmoc-O-tert-butyl-L-tyrosine; fmoc-L-Arg(Pbf)-OH Further stages;
参考文献
Patkar, Kshitij A.; Murray, Thomas F.; Aldrich, Jane V.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6814 - 6821
