4-甲基-4-联苯基羧酸合成路线 （共 32 条）
反应条件
potassium phosphate; 2GLCAphos; PdCl2(GLCAphos) T=80°C; Substitution; 0.5 h;
参考文献
Nishimura, Masato; Ueda, Masato; Miyaura, Norio
Tetrahedron, 2002 , vol. 58, # 29 p. 5779 - 5787
反应条件
potassium fluoride; potassium carbonate in water T=100°C; Suzuki-Miyaura coupling; 5 h;
参考文献
Bernini, Roberta; Cacchi, Sandro; Fabrizi, Giancarlo; Forte, Giovanni; Petrucci, Francesco; Prastaro, Alessandro; Niembro, Sandra; Shafir, Alexandr; Vallribera, Adelina
Green Chemistry, 2010 , vol. 12, # 1 p. 150 - 158
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=80°C; 48 h;
参考文献
Homsi, Fadi; Nozaki, Kyoko; Hiyama, Tamejiro
Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5869 - 5872
反应条件
potassium fluoride; trifuran-2-yl-phosphane; palladium diacetate in N,N-dimethyl-formamide T=120°C; 44 h;
参考文献
Homsi, Fadi; Hosoi, Kazushi; Nozaki, Kyoko; Hiyama, Tamejiro
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 208 - 216
反应条件
sodium hydroxide; sodium carbonate; Pd(PPh3)4 in tetrahydrofuran; methanol; ethylene glycol dimethyl ether; diethyl ether; ethanol; water; acetone
参考文献
US2002/55631 A1, ;
US 20020055631 A1
反应条件
potassium phosphate; 2-(dicyclohexylphosphino)biphenyl based D-gluconamide; palladium diacetate in water T=80°C; 16 h;
参考文献
Nishimura, Masato; Ueda, Masato; Miyaura, Norio
Tetrahedron, 2002 , vol. 58, # 29 p. 5779 - 5787
反应条件
aluminum tri-bromide; triphenyl-silyl chloride in chlorobenzene T=20°C; P=22502.3 Torr; 3 h; Autoclave; regioselective reaction;
参考文献
Nemoto, Koji; Yoshida, Hiroki; Egusa, Naoki; Morohashi, Naoya; Hattori, Tetsutaro
Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7855 - 7862
反应条件
1: With ethylene glycol; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=105°C; Suzuki coupling; 20 h; 2: With trifluoroacetic acid in dichloromethane Further stages.;
参考文献
Gravel, Michael; Thompson, Kim A.; Zak, Mark; Berube, Christian; Hall, Dennis G.
Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 3 - 15
反应条件
sodium carbonate; polystyrene-supported N-heterocyclic carbene-Pd complex in tetrahydrofuran Suzuki cross-coupling; 21 h; Heating;
参考文献
Zhang, Sujuan; Zeng, Xiaoming; Wei, Zhijun; Zhao, Dongbing; Kang, Tairan; Zhang, Weifeng; Yan, Mei; Luo, Meiming
Synlett, 2006 , # 12 p. 1891 - 1894
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide in neat (no solvent) T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere; 2: Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
