2-甲基-4-硝基苯甲醛合成路线 （共 10 条）
反应条件
1: With ozone in dichloromethane
T=-78°C;
2: With dimethylsulfide in dichloromethane
参考文献
Iwanowicz, Edwin J.; Watterson, Scott H.; Guo, Junqing; Pitts, William J.; Murali Dhar; Shen, Zhongqi; Chen, Ping; Gu, Henry H.; Fleener, Catherine A.; Rouleau, Katherine A.; Cheney, Daniel L.; Townsend, Robert M.; Hollenbaugh, Diane L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 12 p. 2059 - 2063
反应条件
sodium acetate; copper(II) sulfate; sodium sulfite
in wss. Loesung und anschl. mit wss. HCl;
参考文献
Fukui et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 5954,5956 Anm.27
反应条件
potassium hydroxide in methanol; water
T=50°C; 120 h; Yield given. Yields of byproduct given;
参考文献
Goh, Swee Hock; Kam, Toh Seok
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 423 - 426
反应条件
potassium hydroxide in water
T=50°C; 120 h; Yield given. Yields of byproduct given;
参考文献
Goh, Swee Hock; Kam, Toh Seok
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 423 - 426
参考文献
Goh, Swee Hock; Kam, Toh Seok
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 423 - 426
反应条件
(i) NBS, (PhCO)2O2, (ii) hexamethylenetetramine, (iii) aq. HCl; Multistep reaction;
参考文献
Goh,S.H.; Gian,H.L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1625 - 1628
反应条件
1.1: Pd2dba3 / toluene / 110 °C
2.1: O3 / CH2Cl2 / -78 °C
2.2: 82 percent / Me2S / CH2Cl2
View Scheme
参考文献
Iwanowicz, Edwin J.; Watterson, Scott H.; Guo, Junqing; Pitts, William J.; Murali Dhar; Shen, Zhongqi; Chen, Ping; Gu, Henry H.; Fleener, Catherine A.; Rouleau, Katherine A.; Cheney, Daniel L.; Townsend, Robert M.; Hollenbaugh, Diane L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 12 p. 2059 - 2063
反应条件
p-(Dimethylamino)-nitrosobenzol-hydrochlorid
参考文献
Goh, Swee Hock; Kam, Toh Seok
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 423 - 426
反应条件
1: boric acid trimethyl ester; dimethylsulfide borane complex / tetrahydrofuran / 2 h / 65 °C / |Inert atmosphere
2: manganese(IV) oxide / dichloromethane / 2 h / 40 °C
View Scheme
参考文献
Allergan, Inc.; Malone, Thomas C.; Wurster, Julie A.; Hull, III, Clarence Eugene
Patent: US2013/310394 A1, 2013 ;
反应条件
chromium(VI) oxide; sulfuric acid; acetic anhydride
1.) glacial acetic acid, 5-8 deg C, 2.) water, ethanol; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Goh, Swee Hock; Kam, Toh Seok
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 423 - 426
