反应条件
1: 52 percent / Br2, HCl / aq. NaOH / 20 °C
2: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
3: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
4: 22 percent / 1.) 1.5 M BuLi; 2.) 2-(phenylsulfonyl)-3-phenyloxaziridine / 1.) Et2O, -50 deg C, hexan, 2h; 2.) -20 deg C, THF, 75 min
5: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
参考文献
Hasseberg, Hans-Albrecht; Gerlach, Hans
Helvetica Chimica Acta, 1988 , vol. 71, p. 957 - 963
