6-氯-1-甲基-1H-咪唑并[4,5-c]吡啶合成路线 （共 4 条）
反应条件
orthoformic acid triethyl ester
T=100°C; 4 h;
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;
Location in patent: Paragraph 00265-00267 ;
参考文献
GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoît Antoine; GENEY, Raphaël Jean Joël; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart
Patent: WO2013/117645 A1, 2013 ;
Location in patent: Paragraph 00314 ;
反应条件
1: tetrahydrofuran / 2 h / 20 °C
2: iron; acetic acid / 50 - 80 °C
3: orthoformic acid triethyl ester / 4 h / 100 °C
View Scheme
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;
反应条件
1: iron; acetic acid / 50 - 80 °C
2: orthoformic acid triethyl ester / 4 h / 100 °C
View Scheme
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;
