4-氨基-5-氯-2-甲氧基苯甲酸合成路线 （共 38 条）
反应条件
1: thionyl chloride / 5 h / 80 °C 2: acetic acid / 5 h / 50 °C View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
sodium; isopropyl alcohol T=70°C; 2 h;
参考文献
Elz; Keller
Archiv der Pharmazie, 1995 , vol. 328, # 7-8 p. 585 - 594
反应条件
1: 71 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / tetrahydrofuran / 3 h / Heating 2: K2CO3 / dimethylformamide / 18 h / Ambient temperature View Scheme
参考文献
Yang, Donglai; Soulier, Jean-Louis; Sicsic, Sames; Mathe-Allainmat, Monique; Bremont, Beatrice; Croci, Tiziano; Cardamone, Rosanna; Aureggi, Giulio; Langlois, Michel
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 608 - 621
反应条件
1: Et3N / tetrahydrofuran / 0.5 h / -10 - -5 °C 2: CH2Cl2 / 25 °C View Scheme
参考文献
Elz; Keller
Archiv der Pharmazie, 1995 , vol. 328, # 7-8 p. 585 - 594
反应条件
chloroformic acid ethyl ester; triethylamine
参考文献
Gradillas, Ana; Lopez, Berta; Brana, Miguel F.; Sancho, Isabel; Perez-Garcia, Carmen; Alguacil, Luis Fernando
Arzneimittel-Forschung/Drug Research, 2005 , vol. 55, # 12 p. 725 - 729
反应条件
1: 60 percent / NaBO3*4H2O, glacial AcOH / 50 - 55 °C 2: SOCl2 View Scheme
参考文献
Maurich, V.; Amici, M. De; Micheli, C. De; Rossato, P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 10 p. 757 - 762
反应条件
methanol; thionyl chloride 16 h; Reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2010/168094 A1, 2010 ;
Location in patent: Page/Page column 66 ;
US 20100168094 A1
反应条件
thionyl chloride T=80°C; 5 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 59 ;
US 20120277224 A1
反应条件
in methanol; hexane; toluene T=0 - 20°C; 16 h;
参考文献
Theravance, Inc.
Patent: US2006/35931 A1, 2006 ;
Location in patent: Page/Page column 12 ;
反应条件
potassium carbonate in dimethyl sulfoxide 4 h; Heating;
参考文献
Ohmori; Maeno; Hidaka; Nakato; Matsumoto; Tada; Hattori; Sakamoto; Tsukamoto; Usuda; Mase
Journal of medicinal chemistry, 1996 , vol. 39, # 14 p. 2764 - 2772
