1-(3-氯吡嗪-2-基)吡咯烷-2-酮合成路线 (共 1 条)
反应条件
1: pyrrolidin-2-one With sodium hydride in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 1.5 h;
2: 2,3-Dichloropyrazine in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/56369 A1, 2004 ;
Location in patent: Page/Page column 23 ;