1: methyllithium; 2-bromo-3-methyl-2-cyclopenten-1-one in tetrahydrofuran
T=-78°C; 2 h;
2: With tert.-butyl lithium in tetrahydrofuran
T=-78°C; 2 h;
3: formaldehyd; methyl iodide With p-methylbenzenesulfonyl (tosylate); sodium hydride
more than 3 stages;
参考文献
LG CHEM. LTD.
Patent: WO2005/35470 A1, 2005 ;
Location in patent: Page/Page column 16-17 ;