2-氯-3,6-二甲基吡啶合成路线 （共 2 条）
反应条件
1: With n-butyllithium; 2-(dimethylamino)-ethanol in hexane
T=-5°C; 0.5 h;
2: 2-chloro-3-methyl-pyridine in hexane
T=-75 - -70°C; 1.5 h;
3: methyl iodide in tetrahydrofuran; hexane
T=-70 - 0°C;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS
Patent: WO2006/65204 A1, 2006 ;
Location in patent: Page/Page column 147; 149-150 ;
WO 2006/065204 A1
反应条件
hydrogenchloride; trichlorophosphate in N,N-dimethyl-formamide
T=125°C;
参考文献
Shvekhgeimer, M.-G. A.; Kobrakov, K. I.; Sychev, S. S.; Promonenkov, V. K.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 4 p. 428 - 433
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 4 p. 514 - 519
