diethyl ether

tributylphosphine; palladium diacetate in 1-methyl-pyrrolidin-2-one T=80°C; 4 h;

T=-78°C;

magnesium ester of trifluoroacetic acid as aduct; Multistep reaction;

1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: 3-(trifluoromethyl)-α,α,α-trifluoroacetophenone in tetrahydrofuran; diethyl ether T=20°C; 5 h;

1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid in acetic acid T=35°C; 3.5 h;

formic acid; triethylamine; Pd(0)EnCat in ethyl acetate T=24°C; 48 h;