2-氨基-4-甲基噻唑-5-甲酸乙酯合成路线 （共 37 条）
反应条件
trimethylsilyl bromide in ethyl acetate; acetonitrile T=0 - 20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/6922 A1, 2004 ;
Location in patent: Page/Page column 34; 35 ;
反应条件
1: 85 percent / 0.5 M ethanolic sodium hydroxide / 24 h / Ambient temperature 2: 47 percent / acetic anhydride / 18 h / Ambient temperature 3: dicyclohexylcarbodiimid / dimethylformamide / Ambient temperature View Scheme
参考文献
Rao; Bathini; Lown
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 728 - 737
反应条件
1: pyridine
2: aqueous methanol. HCl
View Scheme
参考文献
Takahashi; Nishigaki
Yakugaku Zasshi, 1949 , vol. 69, p. 416
Chem.Abstr., 1950 , p. 1923
反应条件
1: H2SO4 / Heating
2: aq. N2H4 / ethanol / Heating
4: K2CO3 / ethane-1,2-diol / 160 °C
View Scheme
参考文献
Sen,A.B.; Chatterjee,S.S.
Journal of the Indian Chemical Society, 1964 , vol. 41, p. 465 - 468
反应条件
in ethanol
T=95°C; 14 h;
参考文献
SANOFI-AVENTIS
Patent: WO2008/58641 A1, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/058641 A1
反应条件
hydrazine hydrate in ethanol
3 h; Reflux;
参考文献
Al-Saadi, Mohammed S.; Faidallah, Hassan M.; Rostom, Sherif A. F.
Archiv der Pharmazie, 2008 , vol. 341, # 7 p. 424 - 434
反应条件
1: H2SO4 / Heating
2: aq. N2H4 / ethanol / Heating
View Scheme
参考文献
Sen,A.B.; Chatterjee,S.S.
Journal of the Indian Chemical Society, 1964 , vol. 41, p. 465 - 468
