H-3-ALA(3-苯并噻吩)-OH合成路线 （共 7 条）
反应条件
sodium hydroxide; cobalt(II) chloride 24 h; Ambient temperatureAcylase, pH 6.5;
参考文献
Kawakubo, Hiromu; Takagi, Seiji; Yamaura, Yuuji; Katoh, Shinichi; Ishimoto, Yumiko; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3526 - 3532
反应条件
1: 62 percent / NaOEt / ethanol 2: 92.9 percent / KOH / H2O 3: 39.3 percent / Acylase Amano 15000, NaOH, CoCl2*6H2O / H2O / 37 °C / pH=7.5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 13 p. 2090 - 2099
反应条件
1: 92.9 percent / KOH / H2O 2: 39.3 percent / Acylase Amano 15000, NaOH, CoCl2*6H2O / H2O / 37 °C / pH=7.5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 13 p. 2090 - 2099
反应条件
1: With propan-1-ol; Candida antarctica B lipase in 1,4-dioxane T=20°C; 2: With sodium carbonate in water 2 h; Heating; 3: With lithium hydroxide; Acylase I; cobalt(II) chloride in water T=37°C; pH=7 - 8; Further stages.;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 4 p. 500 - 511
反应条件
lithium hydroxide; Acylase I; cobalt(II) chloride in water T=37°C; pH=7 - 8; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 4 p. 500 - 511
反应条件
triethylamine in water; acetone
参考文献
Hagiwara, Daijiro; Miyake, Hiroshi; Igari, Norihiro; Karino, Masako; Maeda, Yasue; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 2090 - 2099
反应条件
phenylalanine ammonia-lyase in various solvent(s)
T=30°C; pH=8.8; Enzyme kinetics;
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
