5-溴-4-氯-3-吲哚基-B-D-半乳糖甘(X-gal)合成路线 （共 34 条）
反应条件
1.1: 81 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
2.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
3.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
4.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
5.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
5.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
1.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
2.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
3.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
3.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
1: 85 percent / KOBt / CH2Cl2
2: 74 percent / aq. NaOH / methanol / 3 h
3: 77 percent / thionyl chloride / CH2Cl2 / 24 h
4: 76 percent / KOBt / CH2Cl2 / 0.5 h / Ambient temperature
5: 83 percent / aq. NaOH / methanol / 3 h
6: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
7: 62 percent / KOBt / CH2Cl2 / Ambient temperature
8: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 77 percent / thionyl chloride / CH2Cl2 / 24 h
2: 76 percent / KOBt / CH2Cl2 / 0.5 h / Ambient temperature
3: 83 percent / aq. NaOH / methanol / 3 h
4: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
5: 62 percent / KOBt / CH2Cl2 / Ambient temperature
6: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 76 percent / KOBt / CH2Cl2 / 0.5 h / Ambient temperature
2: 83 percent / aq. NaOH / methanol / 3 h
3: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
4: 62 percent / KOBt / CH2Cl2 / Ambient temperature
5: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 74 percent / aq. NaOH / methanol / 3 h
2: 77 percent / thionyl chloride / CH2Cl2 / 24 h
3: 76 percent / KOBt / CH2Cl2 / 0.5 h / Ambient temperature
4: 83 percent / aq. NaOH / methanol / 3 h
5: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
6: 62 percent / KOBt / CH2Cl2 / Ambient temperature
7: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 62 percent / KOBt / CH2Cl2 / Ambient temperature
2: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
2: 62 percent / KOBt / CH2Cl2 / Ambient temperature
3: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 83 percent / aq. NaOH / methanol / 3 h
2: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
3: 62 percent / KOBt / CH2Cl2 / Ambient temperature
4: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
反应条件
1: 78.8 percent / iBuOCOCl, N-methylmorpholine / tetrahydrofuran / 1.) -15 deg C, 30 min, 2.) 24 h, r.t.
2: 4N HCl / dioxane
3: 75 percent / TEA / dimethylformamide / 48 h
4: 4N HCl / dioxane
5: 89 percent / TEA / dimethylformamide / 48 h
6: 4N HCl / dioxane
7: 76 percent / TEA / dimethylformamide / 48 h
8: 92 percent / H2 / 10percent Pd/C / methanol / 4 h
View Scheme
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
