hydrogen; platinum(IV) oxide in methanol T=20°C; P=1810.02 - 2068.59 Torr; 3.5 h;

Candida antarctica polyacrylamide-immobilized lipase B, Novozyme SP-435 in tert-butyl methyl ether T=28°C; 144 h; Inert atmosphereMolecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;

1: 83 percent / H2 / PtO2 Adams catalyst / ethyl acetate / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr 2: 93 percent / triethylamine / CH2Cl2 / 0.5 h / 0 - 20 °C 3: 91.5 percent / sodium azide / dimethylformamide / 5 h / 68 - 70 °C 4: 98 percent / H2 / PtO2 Adams catalyst / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme

1: 93 percent / triethylamine / CH2Cl2 / 0.5 h / 0 - 20 °C 2: 91.5 percent / sodium azide / dimethylformamide / 5 h / 68 - 70 °C 3: 98 percent / H2 / PtO2 Adams catalyst / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme

1: 91.5 percent / sodium azide / dimethylformamide / 5 h / 68 - 70 °C 2: 98 percent / H2 / PtO2 Adams catalyst / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme

triethylamine in tert-butyl methyl ether T=50°C; 216 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eeenantioselective reaction;

Candida antarctica polyacrylamide-immobilized lipase B, Novozyme SP-435 T=28°C; 12 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eeenantioselective reaction;