(4-硝基苯基)哌嗪-1-基-甲酮合成路线 （共 14 条）
反应条件
1: 4-nitro-benzoic acid With N-bromosuccinmide; triphenylphosphine in dichloromethane T=0 - 5°C; 0.25 h; 2: piperazine With pyridine in dichloromethane T=20°C; 0.5 h;
参考文献
Bandgar; Bettigeri
Synthetic Communications, 2004 , vol. 34, # 16 p. 2917 - 2924
参考文献
Molecular Geriatrics Corporation
Patent: US6214994 B1, 2001 ;
反应条件
in ethanol; water T=20°C; 6.16667 h;
参考文献
Verma, Sanjeev K.; Acharya; Kaushik
Organic Letters, 2010 , vol. 12, # 19 p. 4232 - 4235
反应条件
1: piperazine With Merrifield resin in dichloromethane T=-10 - 20°C; Solid phase reaction; 1 h; 2: 4-nitro-benzoyl chloride With triethylamine in tetrahydrofuran T=20°C; Acylation; Solid phase reaction; 24 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; Solid phase reaction; 0.0833333 h;
参考文献
Tetrahedron Letters, , vol. 40, # 11 p. 2105 - 2108
反应条件
1: SOCl2 / Heating 2: AcOH / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 6 p. 808 - 816
反应条件
in ethanol; dichloromethane T=20°C;
参考文献
Synthesis, , # 3 p. 361 - 363
反应条件
hydrogenchloride in acetone
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2819 - 2823
反应条件
1: piperazine; piperazine Dihydrochloride in water 0.0833333 h; 2: 1-(4-nitrobenzoyl) imidazole With sodium chloride in water 0.5 h; 3: With sodium hydroxide in water chemoselective reaction;
参考文献
Green Chemistry, , vol. 14, # 2 p. 326 - 329
反应条件
hydrogenchloride in dimethyl sulfoxide; acetonitrile T=25°C; Substitution; Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 65, # 18 p. 5659 - 5663
反应条件
potassium chloride in ethanol T=25°C; pH=10.01; Kinetics; Further Variations:pH-valuesconcentrations;
参考文献
Journal of Organic Chemistry, , vol. 68, # 21 p. 8157 - 8161
