5-氯甲基-3-(4-氟苯基)-[1,2,4]噁二唑合成路线 （共 6 条）
反应条件
acetic acid T=160°C; 0.5 h; Microwave;
参考文献
CV THERAPEUTICS, INC.
Patent: WO2009/94028 A1, 2009 ;
Location in patent: Page/Page column 54 ;
WO 2009/094028 A1
反应条件
triethylamine in benzene 10 h; Reflux;
参考文献
Dueruest, Yaar; Karaku, Hamza; Kaiser, Marcel; Tasdemir, Deniz
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 296 - 304
反应条件
acetic acid in chloromethyltrimethylorthoformate
参考文献
Diamond, Ivan; Overstreet, David
Patent: US2009/124672 A1, 2009 ;
US 20090124672 A1
反应条件
in toluene 6 h; Heating;
参考文献
Cottrell, Denise M.; Capers, Jeffrey; Salem, Manar M.; DeLuca-Fradley, Kate; Croft, Simon L.; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2815 - 2824
反应条件
1: DIEA / CH2Cl2 / 24 h / 20 °C 2: toluene / 24 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 3 p. 609 - 612
反应条件
1: 8-hydroxyquinoline; hydroxylamine hydrochloride; sodium carbonate / H2O; ethanol / Heating 2: 81 percent / potassium carbonate / acetone / 6 h / 20 °C 3: 88 percent / toluene / 6 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2815 - 2824
