N-Boc-L-苯丙氨醛合成路线 （共 60 条）
反应条件
sodium hexamethyldisilazane in toluene T=-78 - 20°C;
参考文献
Delcamp, Jared H.; Brucks, Alexandria P.; White, M. Christina
Journal of the American Chemical Society, 2008 , vol. 130, # 34 p. 11270 - 11271
反应条件
potassium tert-butylate; Methyltriphenylphosphonium bromide in tetrahydrofuran; toluene T=-78°C; 1.75 h;
参考文献
Randolph, John T.; Chen, Hui-Ju; DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Huang, Peggy P.; Hutchinson, Douglas K.; Kempf, Dale J.; Klein, Larry L.; Yeung, Ming C.
Patent: US2005/159469 A1, 2005 ;
Location in patent: Page/Page column 89 ;
US 20050159469 A1
反应条件
Wilkinson's catalyst; isopropyl alcohol; 4-diphenylphosphanyl-benzoic acid 2-trimethylsilanyl-ethyl ester in tetrahydrofuran T=25°C; 16 h;
参考文献
Lebel, Helene; Paquet, Valerie
Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 320 - 328
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran; toluene T=25°C; 16 h; 2: [(1S)-1-formyl-2-phenylethyl]-carbamic acid 1,1-dimethylethyl ester in tetrahydrofuran; toluene T=-78 - 25°C; 1.75 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2005/61487 A1, 2005 ;
Location in patent: Page/Page column 114 ;
WO 2005/061487 A1
反应条件
in tetrahydrofuran; dimethyl sulfoxide 1.) -78 deg C, 15 min, 2.) 40 deg C, 12 h;
参考文献
Garro-Helion, Florence; Guibe, Francois
Chemical Communications, 1996 , # 5 p. 641 - 642
反应条件
potassium hexamethylsilazane in tetrahydrofuran; dimethyl sulfoxide T=-78 - 20°C; Wittig reaction;
参考文献
Paige Souder; Evans, Zachary M.; Driver, Joshua A.; Pozzo, Eric J.; Lampkins, Andrew J.
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6908 - 6910
反应条件
potassium hydride; 1,1,1,3,3,3-hexamethyl-disilazane 1.) THF, DMSO, from 0 to -78 deg C, 1 h, 2.) THF, DMSO, from -78 to 40 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Luly, Jay R.; Dellaria, Joseph F.; Plattner, Jacob J.; Soderquist, Jeffrey L.; Yi, Nwe
Journal of Organic Chemistry, 1987 , vol. 52, # 8 p. 1487 - 1492
反应条件
1.1: H2O; ethyl acetate 1.2: 6.45 g / conc. HCl / dioxane / 8 h / Heating 2.1: 32.5 percent / TEA / tetrahydrofuran; H2O View Scheme
参考文献
Yuan; Munoz; Wong; Haeggstrom; Wetterholm; Samuelsson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 2 p. 211 - 220
反应条件
1: 2.) Bu4NF / 1.) THF 2: 19 percent / pyridine, 4-(dimethylamino)pyridine / 16 h / Ambient temperature 3: 13 percent / 1 M NaOH / ethanol / 0.25 h / Ambient temperature 4: 96 percent / acetonitrile / 20 h / Heating 5: NaBH4 / methanol / 1 h / -10 °C 6: HgCl2 / acetonitrile; H2O / 0.25 h 7: NaCNBH3, 1 M HCl, 3-Angstroem molecular sieves / methanol / 112 h / Ambient temperature 8: 86 percent / trifluoroacetic acid / 1 h / Ambient temperature View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
1: 2.) Bu4NF / 1.) THF 2: 19 percent / pyridine, 4-(dimethylamino)pyridine / 16 h / Ambient temperature 3: 13 percent / 1 M NaOH / ethanol / 0.25 h / Ambient temperature 4: 96 percent / acetonitrile / 20 h / Heating 5: NaBH4 / methanol / 1 h / -10 °C 6: HgCl2 / acetonitrile; H2O / 0.25 h 7: NaCNBH3, 1 M HCl, 3-Angstroem molecular sieves / methanol / 112 h / Ambient temperature 8: 86 percent / trifluoroacetic acid / 1 h / Ambient temperature 9: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature 10: H2 / 10percent Pd/C / ethanol / 16 h 11: 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
