2,4,5-三脱氧-4-[[(1,1-二甲基乙氧基)羰基]氨基]-5-苯基-L-苏-戊糖酸合成路线 （共 42 条）
反应条件
1: 96 percent / diisobutylaluminium hydride / hexane; CH2Cl2 / 0.1 h / -78 °C 2: 8 percent / Zn / tetrahydrofuran / 0.75 h / Heating 3: 98 percent / NaOH / tetrahydrofuran / 2 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 10 p. 789 - 800
反应条件
1: DMAP / CHCl3 2: 92 percent / 1N NaOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 775 - 776
反应条件
1: tetrahydrofuran 2: NaOH, H2O2 / H2O 3: Na, NH3 4: NaOH / dioxane; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 32 p. 5127 - 5130
反应条件
silica gel; potassium carbonate Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 12 p. 3395 - 3399
反应条件
1: 85 percent / isopropenyl chloroformate, 4-N,N-dimethylaminopyridine / CH2Cl2 / 3 h / -5 °C 2: 95 percent / methanol / 0.33 h / Heating 3: sodium borohydride / CH2Cl2; acetic acid / 5 h 4: 87 percent / NaOH / acetone / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1177 - 1182
反应条件
1: sodium borohydride / CH2Cl2; acetic acid / 5 h 2: 87 percent / NaOH / acetone / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1177 - 1182
反应条件
1: 95 percent / methanol / 0.33 h / Heating 2: sodium borohydride / CH2Cl2; acetic acid / 5 h 3: 87 percent / NaOH / acetone / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1177 - 1182
反应条件
1.1: methanol; toluene-4-sulfonic acid / 1 h / 20 °C 2.1: water; sodium hydroxide / tetrahydrofuran / 1 h / 20 °C 2.2: Cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1700 - 1704
反应条件
sodium hydroxide; hydrogen bromide 1.) 80 deg C, 20 h, 2.) water, THF, 24 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 58, # 15 p. 4010 - 4012
反应条件
hydrogen; rhodium on alumina in ethanol P=3040 - 3800 Torr; 16 h; Yield given;
参考文献
Boger, Joshua; Payne, Linda S.; Perlow, Debra S.; Lohr, Nancy S.; Poe, Martin; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1779 - 1790
