(2S,4S)-4-氟-1,2-吡咯烷二羧酸 2-甲基 1-(苯基甲基)酯合成路线 （共 6 条）
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=-78 - 20°C;
参考文献
WO2005/121135 A1, ;
Page/Page column 68 ;
反应条件
in dichloromethane T=20°C; 1 h;
参考文献
WO2010/81014 A1, ;
Page/Page column 33 ;
反应条件
1: Fluolead / dichloromethane / 61 h / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 9 p. 3113 - 3121
反应条件
1: potassium carbonate / tetrahydrofuran; water / 20 h / 20 °C 2: thionyl chloride / 20.25 h / 0 - 20 °C 3: diethylamino-sulfur trifluoride / dichloromethane / 21 h / -78 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 48 p. 13433 - 13437
反应条件
1: potassium carbonate / tetrahydrofuran; water / 20 h / 20 °C 2: thionyl chloride / 20.25 h / 0 - 20 °C 3: diethylamino-sulfur trifluoride / dichloromethane / 21 h / -78 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 48 p. 13433 - 13437
反应条件
1: methyl (2S,4S)-N-Cbz-4-fluoropyrrolidine-2-carboxylate With hydrogen; palladium on activated charcoal in ethanol T=20°C; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=20°C; 3 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/121135 A1, 2005 ;
Location in patent: Page/Page column 68-69 ;
