1-氨基-3,4-二甲基-1H-吡咯-2-羧酰胺合成路线 （共 3 条）
反应条件
1.1: POCl3 / 1,2-dichloro-ethane / Heating
2.1: aq. hydroxylamine O-sulfonic acid
2.2: O-mesitylenesulfonylhydroxylamine
2.3: NaH / CH2Cl2
3.1: aq. KOH
View Scheme
参考文献
Hunt, John T.; Mitt, Toomas; Borzilleri, Robert; Gullo-Brown, Johnni; Fargnoli, Joseph; Fink, Brian; Han, Wen-Ching; Mortillo, Steven; Vite, Gregory; Wautlet, Barri; Wong, Tai; Yu, Chiang; Zheng, Xiaoping; Bhide, Rajeev
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4054 - 4059
参考文献
Hunt, John T.; Mitt, Toomas; Borzilleri, Robert; Gullo-Brown, Johnni; Fargnoli, Joseph; Fink, Brian; Han, Wen-Ching; Mortillo, Steven; Vite, Gregory; Wautlet, Barri; Wong, Tai; Yu, Chiang; Zheng, Xiaoping; Bhide, Rajeev
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4054 - 4059
反应条件
1.1: aq. hydroxylamine O-sulfonic acid
1.2: O-mesitylenesulfonylhydroxylamine
1.3: NaH / CH2Cl2
2.1: aq. KOH
View Scheme
参考文献
Hunt, John T.; Mitt, Toomas; Borzilleri, Robert; Gullo-Brown, Johnni; Fargnoli, Joseph; Fink, Brian; Han, Wen-Ching; Mortillo, Steven; Vite, Gregory; Wautlet, Barri; Wong, Tai; Yu, Chiang; Zheng, Xiaoping; Bhide, Rajeev
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4054 - 4059
