1: 99.5 percent / pyridine / 15 h / -10 °C 2: Li2CuCl4 / 1) THF -78 deg C, 2 hours 2) room temperature 15 h 3: 11.7 g / 5percent aq. HCl / acetone / 6 h / Ambient temperature 4: diisobutylaluminum hydride / diethyl ether / 1.5 h / -10 °C 5: 43 percent / pyridine / diethyl ether / 12 h / Ambient temperature; 1) 5 deg C, 1 h 2) room temperature 12 h 6: CuI, 2,2'-bipyridyl / 2 deg C, 2 h, THF View Scheme

pyridine T=-10°C; 15 h;

1: 99.5 percent / pyridine / 15 h / -10 °C 2: Li2CuCl4 / 1) THF -78 deg C, 2 hours 2) room temperature 15 h 3: 11.7 g / 5percent aq. HCl / acetone / 6 h / Ambient temperature View Scheme

1: 91 percent / pyridine / 2 h / 0 °C 2: 1) Mg 2) LiCl, CuCl2 / 1) THF 2) 3h, 0 deg C 3: 98 percent / HCl / acetone / 1 h / Ambient temperature 4: 1) dimsylpotassium (KH, DMSO) / 1) DMSO 2) DMSO, THF, 2h View Scheme