5’-羧基-2-氯-2’-3’-O-异亚丙基腺苷酸合成路线 （共 3 条）
反应条件
1: SOCl2 / dimethylformamide / 2 h / 50 °C 2: CH2Cl2 / 1 h / Ambient temperature 3: 55 percent / 3 h / 130 °C 4: 96 percent / 1 N HCl / 1 h / 65 °C View Scheme
参考文献
Hutchison, Alan J.; Williams, Michael; Jesus, Reynalda, de; Yokoyama, Rina; Oei, Howard H.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1919 - 1924
反应条件
potassium hydroxide; potassium permanganate in water
72 h;
参考文献
Hutchison, Alan J.; Williams, Michael; Jesus, Reynalda, de; Yokoyama, Rina; Oei, Howard H.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1919 - 1924
反应条件
1: 58 percent / camphorsulfonic acid / acetone / 16 h / Ambient temperature
2: 74 percent / aq. KOH, KMnO4 / H2O / 72 h
View Scheme
参考文献
Hutchison, Alan J.; Williams, Michael; Jesus, Reynalda, de; Yokoyama, Rina; Oei, Howard H.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1919 - 1924
