potassium hydroxide in dimethyl sulfoxide T=110°C; 4 h;

(2S)-3-Methyl-2-(methylcarbonyl)aminobutyric acid; palladium diacetate; lithium carbonate; N,N-dimethyl-formamide; silver carbonate in tert-butyl alcohol T=110°C; 2 h; Schlenk techniqueInert atmosphere;

1: 72 percent / CH2Cl2 / 0.25 h / 0 °C 2: 100 percent / diethyl ether / Ambient temperature 3: 100 percent / 2.0M KOH / dimethylsulfoxide / 4 h / 110 °C View Scheme

1: 100 percent / diethyl ether / Ambient temperature 2: 100 percent / 2.0M KOH / dimethylsulfoxide / 4 h / 110 °C View Scheme