1-(4-羟基苄基)吡咯烷合成路线 （共 5 条）
反应条件
1: With sodium tris(acetoxy)borohydride in dichloromethane
T=0°C; 20 h;
2: With hydrogenchloride; water in dichloromethane
3: With potassium carbonate in water
pH=9; Product distribution / selectivity;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2006/136924 A1, 2006 ;
Location in patent: Page/Page column 162 ;
WO 2006/136924 A1
反应条件
sulfuric acid; sodium nitrite in water
T=0 - 85°C; 0.833333 h;
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
反应条件
1: 70 percent / Fe, 10percent FeCl3 / ethanol; H2O / 15 h / Heating
2: 46 percent / 1M H2SO4, NaNO2 / H2O / 0.83 h / 0 - 85 °C
View Scheme
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
反应条件
1: 75 percent / K2CO3 / acetone / 46 h / Heating
2: 70 percent / Fe, 10percent FeCl3 / ethanol; H2O / 15 h / Heating
3: 46 percent / 1M H2SO4, NaNO2 / H2O / 0.83 h / 0 - 85 °C
View Scheme
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
反应条件
sodium tetrahydroborate
参考文献
Sheng, Rong; Lin, Xiao; Li, Jingya; Jiang, Yanke; Shang, Zhicai; Hu, Yongzhou
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3834 - 3837
