9-甲氧基-5,11-二甲基-2,6-二氢-1H-吡啶并[4,3-b]咔唑-1-酮合成路线 （共 3 条）
反应条件
hydrogenchloride
28 h; Heating;
参考文献
Dormoy; Heymes
Tetrahedron, 1993 , vol. 49, # 14 p. 2915 - 2938
反应条件
1: 54 percent / pyridine hydrochloride / 0.5 h / 220 - 230 °C / Heating
2: 65 percent / pyridine / 1 h / Heating
3: 72 percent / phosphorus oxychloride / 3 h / Heating
4: 2 h / 160 °C
View Scheme
参考文献
Rivalle, Christian; Wendling, Francoise; Tambourin, Pierre; Lhoste, Jean-Marc; Bisagni, Emile; Chermann, Jean-Claude
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 181 - 185
反应条件
1: 54 percent / pyridine hydrochloride / 0.5 h / 220 - 230 °C / Heating
2: 65 percent / pyridine / 1 h / Heating
3: 72 percent / phosphorus oxychloride / 3 h / Heating
4: 1.) NaH / 1.) dimethylacetamide, -15 deg C, 30 min, 2.) dimethylacetamide, -15 deg C, 15 h
5: 76 percent / 3 h / 160 °C
View Scheme
参考文献
Rivalle, Christian; Wendling, Francoise; Tambourin, Pierre; Lhoste, Jean-Marc; Bisagni, Emile; Chermann, Jean-Claude
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 181 - 185
