Multi-step reaction with 7 steps 1: 1.) ethylmagnesium bromide, copper(I) bromide / 1.) THF, -78 -> 25 deg C, 2.) -78 -> 25 deg C2: H2 / Lindlar catalyst / hexane / 25 °C3: KF / dimethylformamide / 25 °C4: 90 percent / n-propylamine / tetrakis<triphenylphosphine>palladium, copper(I) iodide / benzene / 12 h / 25 °C5: 60 percent / H2 / Lindlar catalyst / hexane / 25 °C6: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 25 °C7: 90 percent / LiOH / tetrahydrofuran; H2O / 25 °C  

Multi-step reaction with 5 steps 1: KF / dimethylformamide / 25 °C2: 90 percent / n-propylamine / tetrakis<triphenylphosphine>palladium, copper(I) iodide / benzene / 12 h / 25 °C3: 60 percent / H2 / Lindlar catalyst / hexane / 25 °C4: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 25 °C5: 90 percent / LiOH / tetrahydrofuran; H2O / 25 °C  

Stage #1: With  Fe(III)PPIX(OH); recombinant human cyclooxygenase-2; tris(hydroxymethyl)methylamine hydrochloride; Aspirin; phenol T=20°C; pH=8; 0.0833333 h;  aq. bufferEnzymatic reaction; Stage #2: With  acetic acid in  methanol pH=4;  aq. buffer;