1-[4-[2-(2-苯基乙基)苯氧基]丁基]哌啶-4-甲酰胺合成路线 （共 5 条）
反应条件
triethylamine in tetrahydrofuran; water
T=70°C; 10 h;
参考文献
Kikumoto, Ryoji; Hara, Hiroto; Ninomiya, Kunihiro; Osakabe, Masanori; Sugano, Mamoru; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1818 - 1823
反应条件
1: H2 / 5percent Pd/C / ethanol / 20 h
2: 90.8 percent / KOH / H2O; 2-methyl-propan-2-ol / 2 h / Heating
3: 71 percent / Et3N / tetrahydrofuran; H2O / 10 h / 70 °C
View Scheme
参考文献
Kikumoto, Ryoji; Hara, Hiroto; Ninomiya, Kunihiro; Osakabe, Masanori; Sugano, Mamoru; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1818 - 1823
反应条件
1: DBU / acetonitrile / 4 h / Heating
2: H2 / 5percent Pd/C / ethanol / 20 h
3: 90.8 percent / KOH / H2O; 2-methyl-propan-2-ol / 2 h / Heating
4: 71 percent / Et3N / tetrahydrofuran; H2O / 10 h / 70 °C
View Scheme
参考文献
Kikumoto, Ryoji; Hara, Hiroto; Ninomiya, Kunihiro; Osakabe, Masanori; Sugano, Mamoru; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1818 - 1823
反应条件
1: 95 percent / acetonitrile / 5 h / Heating
2: DBU / acetonitrile / 4 h / Heating
3: H2 / 5percent Pd/C / ethanol / 20 h
4: 90.8 percent / KOH / H2O; 2-methyl-propan-2-ol / 2 h / Heating
5: 71 percent / Et3N / tetrahydrofuran; H2O / 10 h / 70 °C
View Scheme
参考文献
Kikumoto, Ryoji; Hara, Hiroto; Ninomiya, Kunihiro; Osakabe, Masanori; Sugano, Mamoru; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1818 - 1823
反应条件
1: 90.8 percent / KOH / H2O; 2-methyl-propan-2-ol / 2 h / Heating
2: 71 percent / Et3N / tetrahydrofuran; H2O / 10 h / 70 °C
View Scheme
参考文献
Kikumoto, Ryoji; Hara, Hiroto; Ninomiya, Kunihiro; Osakabe, Masanori; Sugano, Mamoru; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1818 - 1823
