5-甲氧基-1,3-苯并二恶茂合成路线 （共 19 条）
反应条件
1: phosphorus oxychloride / chlorobenzene / 24 h / Ambient temperature
2: 80 percent / 85percent formic acid; 30percent H2O2 / 16 h / 5 °C
3: anh. K2CO3 / acetone / 6 h / Heating
View Scheme
参考文献
Devakumar, C.; Saxena, V. S.; Mukerjee, S. K.
Agricultural and Biological Chemistry, 1985 , vol. 49, # 3 p. 725 - 730
反应条件
1.1: CH2Cl2 / 0 °C
1.2: 90 percent / titanium tetrachloride / CH2Cl2 / 20 °C
2.1: 99 percent / sodium borohydride / ethanol / 0 - 20 °C
View Scheme
参考文献
Aslam, Shazia N.; Stevenson, Philip C.; Phythian, Sara J.; Veitch, Nigel C.; Hall, David R.
Tetrahedron, 2006 , vol. 62, # 17 p. 4214 - 4226
反应条件
1: 92 percent / NBS / CHCl3
2: 90 percent / n-BuLi
View Scheme
参考文献
SmithKline Beecham Corporation
Patent: US2003/4202 A1, 2003 ;
US 20030004202 A1
反应条件
titanium tetrachloride
2 h; Ambient temperature;
参考文献
Schuda, Paul Francis; Price, William A.
Journal of Organic Chemistry, 1987 , vol. 52, # 10 p. 1972 - 1979
反应条件
trichlorophosphate
2.5 h; Heating;
参考文献
Okwute, S. K.; Okogun, J. I.; Okorie, D. A.
Tetrahedron, 1984 , vol. 40, # 13 p. 2541 - 2546
反应条件
trichlorophosphate in chlorobenzene
24 h; Ambient temperature; Yield given;
参考文献
Devakumar, C.; Saxena, V. S.; Mukerjee, S. K.
Agricultural and Biological Chemistry, 1985 , vol. 49, # 3 p. 725 - 730
反应条件
1: sesamol methyl ether With n-butyllithium in tetrahydrofuran
T=-20°C; 1 h;
2: methyl iodide in tetrahydrofuran
T=-20 - 20°C; Further stages.;
参考文献
Christian, R. Razafindrabe; Sylvain, Aubry; Benjamin, Bourdon; Marta, Andriantsiferana; Stephane, Pellet-Rostaing; Marc, Lemaire
Science China Chemistry, 2010 , vol. 53, # 9 p. 1888 - 1898
反应条件
1: 70 percent / phosphorus oxychloride / 2.5 h / Heating
2: 60 percent / zinc, iodine / tetrahydrofuran / 2 h / Heating
3: 44 percent / 2N methanolic KOH / 3 h / Heating
4: oxalyl chloride / benzene / 2 h / Heating
5: benzene / Ambient temperature
View Scheme
参考文献
Okwute, S. K.; Okogun, J. I.; Okorie, D. A.
Tetrahedron, 1984 , vol. 40, # 13 p. 2541 - 2546
反应条件
1: 70 percent / phosphorus oxychloride / 2.5 h / Heating
2: 60 percent / zinc, iodine / tetrahydrofuran / 2 h / Heating
3: 44 percent / 2N methanolic KOH / 3 h / Heating
4: oxalyl chloride / benzene / 2 h / Heating
View Scheme
参考文献
Okwute, S. K.; Okogun, J. I.; Okorie, D. A.
Tetrahedron, 1984 , vol. 40, # 13 p. 2541 - 2546
