1-(2-萘甲酰基 )乙醇合成路线 （共 127 条）
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 1.5 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Kano, Taichi; Sasaki, Kouji; Maruoka, Keiji
Organic Letters, 2005 , vol. 7, # 7 p. 1347 - 1349
反应条件
1-methyl-1H-imidazole in tetrahydrofuran T=20°C; 2 h; Inert atmosphereAnhydrous conditions; enantioselective reaction;
参考文献
Leclercq, Loic; Suisse, Isabelle; Agbossou-Niedercorn, Francine
European Journal of Organic Chemistry, 2010 , # 14 p. 2696 - 2700
反应条件
(R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 8 h; Product distribution; Further Variations:Reagents;
参考文献
Birman, Vladimir B.; Li, Ximin
Organic Letters, 2006 , vol. 8, # 7 p. 1351 - 1354
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Inert atmosphereAnhydrous conditions; optical yield given as percent eeenantioselective reaction;
参考文献
Leclercq, Loic; Suisse, Isabelle; Agbossou-Niedercorn, Francine
European Journal of Organic Chemistry, 2010 , # 14 p. 2696 - 2700
反应条件
vinyl acetate; 4 Anstroem molecular sives; lipase LIP in di-isopropyl ether T=30°C; 0.5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kato; Katayama; Fujii; Kimoto
Bioscience, biotechnology, and biochemistry, 1995 , vol. 59, # 11 p. 2178 - 2180
反应条件
tertiary amine-based nucleophilic catalyst in 1,1-dimethylpropan-1-ol T=0°C; 15 h;
参考文献
Jeong, Kyu-Sung; Kim, Soong-Hyun; Park, Hyun-Jin; Chang, Kyoung-Jin; Kwan, Soo Kim
Chemistry Letters, 2002 , # 11 p. 1114 - 1115
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Inert atmosphereAnhydrous conditions; optical yield given as percent ee;
参考文献
Leclercq, Loic; Suisse, Isabelle; Agbossou-Niedercorn, Francine
European Journal of Organic Chemistry, 2010 , # 14 p. 2696 - 2700
反应条件
(R)-(+)-N-methylbenzoguanidine; trimethylacetic anhydride in diethyl ether T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Nakata, Kenya; Shiina, Isamu
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 7092 - 7096
反应条件
triphenylphosphine; diethylazodicarboxylate in dichloromethane T=-23 - 20°C; Mitsunobu reaction;
参考文献
Chandrasekhar, Sosale; Kulkarni, Guruprasad
Tetrahedron Asymmetry, 2002 , vol. 13, # 6 p. 615 - 619
反应条件
(5aS,10bR)-5a,10b-dihydro-2-(pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium tetrafluoroborate; 3-benzylriboflavin tetraacetate; triethylamine in toluene T=20°C; 4 h; Resolution of racemateAirMolecular sieve; optical yield given as percent eeenantioselective reaction;
参考文献
Iwahana, Soichiro; Iida, Hiroki; Yashima, Eiji
Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 8009 - 8013
