7-氨基-1,2,3,4-四氢异喹啉合成路线 （共 9 条）
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in ethanol P=2585.7 Torr; 4 h;
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Caldwell, Timothy M.; Criscione, Kevin R.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 3997 - 4005
反应条件
potassium carbonate in ethanol; water 1.5 h; Heating / reflux;
参考文献
Butora, Gabor; Goble, Stephen D.; Pastemak, Alexander; Yang, Lihu; Zhou, Changyou; Moyes, Christopher R.
Patent: US2008/81803 A1, 2008 ;
Location in patent: Page/Page column 71 ;
US 20080081803 A1
反应条件
iron; ammonium chloride in ethanol; water T=60°C; 24 h;
参考文献
WO2009/62658 A1, ;
Page/Page column 37 ;
WO 2009/062658 A1
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 2.) 75-80 deg C, 1.5 h; Yield givenMultistep reaction;
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Jalluri, Ravi K.; Criscione, Kevin R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 118 - 134
反应条件
acetic acid in 1,4-dioxane; water T=20°C; pH=4.5; regioselective reaction;
参考文献
Synthesis, , # 2 p. 283 - 289
反应条件
1: 1,2,3,4-Tetrahydro-isoquinolin-7-ylamine With hydrogenchloride in water T=-5 - 0°C; 2: With sodium nitrate in water T=0°C; 1 h; 3: potassium cyanide
参考文献
Gruenenthal GmbH
Patent: US2010/234340 A1, 2010 ;
Location in patent: Page/Page column 21-22 ;
US 20100234340 A1
反应条件
hydrogenchloride; sodium hydroxide; O4S(2-)*2Ni(1+); sodium nitrite 1.) from 0 deg C to 5 deg C, 15 min, 2.) benzene, a) from 5 deg C to RT, 2 h, b) from RT to 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Caldwell, Timothy M.; Criscione, Kevin R.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 3997 - 4005
反应条件
in tetrahydrofuran T=20°C; 3 h;
参考文献
RESPIRATORIUS AB
Patent: WO2007/11290 A1, 2007 ;
Location in patent: Page/Page column 13-15 ;
WO 2007/011290 A1
参考文献
SmithKline Corporation
Patent: US4321254 A1, 1982 ;
