1: 5,5-dibromomeldrum's acid; hydrogenchloride / diethyl ether / 24 h / 20 °C 2: sodium acetate / water; methanol / 3 h / 45 °C 3: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere 4: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 6 h / 20 °C View Scheme

1: 5,5-dibromomeldrum's acid; hydrogenchloride / diethyl ether / 24 h / 20 °C 2: sodium acetate / water; methanol / 3 h / 45 °C 3: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere View Scheme

1: 2.) Et3N / 1.) toluene, reflux, 1 h, 2.) toluene, reflux, 21 h 2: 45 percent / NaOH / H2O; methanol / 16 h / 25 - 27 °C View Scheme