6-溴-4-氯-3-硝基喹啉合成路线 （共 10 条）
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in acetonitrile T=0 - 100°C; 2 h;
参考文献
PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 142 ;
WO 2009/155527 A2
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C 2: trichlorophosphate / 0.75 h / 120 °C View Scheme
参考文献
WO2012/7926 A1, ;
WO 2012/007926 A1
US2012/108627 A1, ;
WO2012/77031 A1, ;
WO 2012/077031 A1
反应条件
1: potassium acetate / acetic anhydride / 3 h / 120 °C 2: trichlorophosphate / 0.75 h / 120 °C View Scheme
参考文献
WO2011/1212 A1, ;
WO 2011/001212 A1
反应条件
1: hydrogenchloride / water / 24 h / 20 °C 2: 24 h / 20 °C 3: acetic anhydride; sodium acetate / 2 h / 120 °C 4: trichlorophosphate / 0.75 h / Reflux View Scheme
参考文献
WO2012/116237 A2, ;
WO 2012/116237 A2
反应条件
1.1: ethanol / 0.17 h / 90 °C 1.2: 0.5 h 2.1: diphenylether / 0.08 h / 220 °C 3.1: nitric acid / propionic acid / 2 h / 125 °C 4.1: trichlorophosphate; triethylamine / 1.5 h / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 3 p. 799 - 807
反应条件
1: nitric acid / propionic acid / 2 h / 125 °C 2: trichlorophosphate; triethylamine / 1.5 h / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 3 p. 799 - 807
反应条件
1: 24 h / 20 °C 2: acetic anhydride; sodium acetate / 2 h / 120 °C 3: trichlorophosphate / 0.75 h / Reflux View Scheme
参考文献
WO2012/116237 A2, ;
WO 2012/116237 A2
反应条件
in acetic acid T=25°C; 0.5 h;
参考文献
PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 264 ;
WO 2009/155527 A2
反应条件
1: acetic acid / 2 h
2: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
3: triethylamine / dichloromethane / 1 h / 0 °C
4: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: acetic acid / 2 h
2: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
